22. Michigan: Serena Williams (Saginaw)
Born in Saginaw before her family moved to Compton, California, Williams completely revolutionized the sport of women’s tennis with her overwhelming power, athleticism, and mental toughness. Across a career spanning over two decades, she captured 23 Grand Slam singles titles—the most by any player in the Open Era. With four Olympic gold medals and countless doubles championships alongside her sister Venus, she is widely regarded as the greatest female athlete of all time.